![]() This study identifies a complex responsible for the snRNA 3’ end maturation in plants and uncovers a previously unknown function of CPSF73 in snRNA maturation. However, the DSP1 complex does not affect pre-mRNA 3’ end cleavage, suggesting that plants may use different CPSF73-I-containing complexes to process snRNAs and premRNAs. Wei Tang, Gen Chen, Zhenhua Chen, Qian Liu, Minghui Yang, Yunfeng Lu. The catalytic component of this complex is likely the cleavage and polyadenylation specificity factor 73 kDa-I (CSPF73-I), which is the nuclease cleaving the pre-mRNA 3’ end. Qiangjian Ju, Ruguang Ma, Yu Pei, Beibei Guo, Zichuang Li, Qian Liu, Tiju Thomas. ![]() L1-ORF1p, a Smad4 Interaction Protein, Promotes Proliferation of. We further show that DSP1 forms a conserved complex, which contains at least four additional proteins, to catalyze snRNA 3’ end maturation in Arabidopsis. Yunfeng Zhu, Fan Feng, Jiyun Yu, Bin Song, Mingming Hu, Xudong Gao,Yue Wang, and Qing Zhang. In addition, DSP1 binds snRNA loci and interacts with Pol-II in a DNA/RNA-dependent manner. A hypomorphic dsp1-1 mutation causes pleiotropic developmental defects, impairs the 3’ end processing of snRNAs, increases the levels of snRNA primary transcripts (pre-snRNAs), and alters the occupancy of Pol II at snRNA loci. Authors: Li, YC (Li, Yu-Chun) Tian, JY (Tian, Jiao-Yang) Liu, FW (Liu, Feng-Wen) Yang, BY (Yang, Bin-Yu) Gu, KSY (Gu, Kang-Shu-Yun) Rahman, ZU (Rahman. Here, we show that DEFECTIVE in snRNA PROCESSING 1 (DSP1) is an essential protein for snRNA 3’ end maturation in Arabidopsis. However, the protein factors responsible for this process remain elusive in plants. The biogenesis of the majority of snRNAs involves 3’ end endonucleolytic cleavage of the nascent transcript from the elongating DNA-dependent RNA ploymerase II. ![]() Fang-Jing Wu, Chien-Pu Lin, Yu-Chee Tseng, Wen-Chih Peng, and Te-Chuan Liu. Hongkai Ning, Zhihao Yu, Taotao Li, Haoliang Shen, Gen Long, Yi Shi, Xinran Wang, From Lab to Fab: the Path Forward for 2D Material Electronics, SCIENCE CHINA Information Sciences, 66, 6, 160411 (2023). Uridine-rich small nuclear RNAs (snRNAs) are the basal components of the spliceosome and play essential roles in splicing. Yunfeng Huang and Fang-Jing Wu, CRISIS: Cyber-physical Social Distancing.
0 Comments
Leave a Reply. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |